AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.

@article{Arencibia2013AGCPK,
  title={AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.},
  author={Jose M Arencibia and Daniel Pastor-Flores and Angelika F Bauer and J{\"o}rg O. Schulze and Ricardo M Biondi},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1834 7},
  pages={1302-21}
}
The group of AGC protein kinases includes more than 60 protein kinases in the human genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK, NDR, MAST, YANK, DMPK, GRK and SGK494. This group is also widely represented in other eukaryotes, including causative organisms of human infectious diseases. AGC kinases are involved in diverse cellular functions and are potential targets for the treatment of human diseases such as cancer, diabetes, obesity, neurological… CONTINUE READING
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