AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton.

@article{Nie2002AGAP1AE,
  title={AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton.},
  author={Zhongzhen Nie and Katherine T Stanley and Stacey Stauffer and Kerry M Jacques and Dianne Snow Hirsch and Jiro Takei and Paul A Randazzo},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 50},
  pages={48965-75}
}
We have identified three members of the AGAP subfamily of ASAP family ADP-ribosylation factor GTPase-activating proteins (Arf GAPs). In addition to the Arf GAP domain, these proteins contain GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains. Here, we have characterized the ubiquitously expressed AGAP1/KIAA1099. AGAP1 had Arf GAP activity toward Arf1>Arf5>Arf6. Phosphatidylinositol 4,5-bisphosphate and phosphatidic acid synergistically stimulated GAP activity. As found for… CONTINUE READING
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