AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

@article{Medema2000AFXlikeFT,
  title={AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1},
  author={Ren{\'e} H. Medema and Geert J.P.L. Kops and Johannes L Bos and Boudewijn M. T. Burgering},
  journal={Nature},
  year={2000},
  volume={404},
  pages={782-787}
}
The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a Forkhead factor that regulates longevity in Caenorhabditis elegans. Here we show that overexpression of these Forkhead transcription factors causes growth suppression in a variety of cell lines, including a Ras-transformed cell line and a cell line lacking the tumour suppressor PTEN. Expression of AFX blocks cell-cycle progression at phase G1, independent of functional retinoblastoma protein (pRb) but… 
Cell cycle and death control: long live Forkheads.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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