AFP-specific immunotherapy impairs growth of autochthonous hepatocellular carcinoma in mice.


BACKGROUND AND AIMS In this study, we have assessed the potential of antigen-specific immunotherapy against hepatocellular carcinoma (HCC) in conditions of low tumour burden, in an autochthonous HCC model. METHODS Diethylnitrosamine (DEN) injected into infant mice results in the development of multi-nodular HCC in which alpha-fetoprotein (AFP) is re… (More)
DOI: 10.1016/j.jhep.2010.06.027

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