AFM study of interaction forces in supported planar DPPC bilayers in the presence of general anesthetic halothane.

@article{Leonenko2006AFMSO,
  title={AFM study of interaction forces in supported planar DPPC bilayers in the presence of general anesthetic halothane.},
  author={Zoya V. Leonenko and Eric Finot and David Thomas Cramb},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1758 4},
  pages={487-92}
}
In spite of numerous investigations, the molecular mechanism of general anesthetics action is still not well understood. It has been shown that the anesthetic potency is related to the ability of an anesthetic to partition into the membrane. We have investigated changes in structure, dynamics and forces of interaction in supported dipalmitoylphosphatidylcholine (DPPC) bilayers in the presence of the general anesthetic halothane. In the present study, we measured the forces of interaction… CONTINUE READING

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