AFM phase imaging of soft-hydrated samples: a versatile tool to complete the chemical-physical study of liposomes.

@article{Ruozi2009AFMPI,
  title={AFM phase imaging of soft-hydrated samples: a versatile tool to complete the chemical-physical study of liposomes.},
  author={Barbara Ruozi and Giovanni Tosi and Massimo Tonelli and Lucia Bondioli and Adele Mucci and Flavio Forni and Maria Angela Vandelli},
  journal={Journal of liposome research},
  year={2009},
  volume={19 1},
  pages={59-67}
}
Despite of the several approaches applied to the physicochemical characterization of liposomes, few techniques are really useful to obtain information about the surface properties of these colloidal drug-delivery systems. In this paper, we demonstrate a possible new application of tapping mode atomic force microscopy (AFM) to discriminate between conventional and pegylated liposomes. We showed that the differences on liposomal surface properties revealed by the phase images AFM approach well… CONTINUE READING

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