AFM investigation of Pseudomonas aeruginosa lectin LecA (PA-IL) filaments induced by multivalent glycoclusters.

@article{Sicard2011AFMIO,
  title={AFM investigation of Pseudomonas aeruginosa lectin LecA (PA-IL) filaments induced by multivalent glycoclusters.},
  author={Delphine Sicard and Samy Cecioni and Maksym Iazykov and Yann Chevolot and Susan E Matthews and Jean-Pierre Praly and {\'E}liane Souteyrand and Anne Imberty and S{\'e}bastien Vidal and Magali Phaner-Goutorbe},
  journal={Chemical communications},
  year={2011},
  volume={47 33},
  pages={
          9483-5
        }
}
Atomic force microscopy reveals that Pseudomonas aeruginosa LecA (PA-IL) and a tetra-galactosylated 1,3-alternate calix[4]arene-based glycocluster self-assemble according to an aggregative chelate binding mode to create monodimensional filaments. Lectin oligomers are identified along the filaments and defects in chelate binding generate branches and bifurcations. A molecular model with alternate 90° orientation of LecA tetramers is proposed to describe the organisation of lectins and… CONTINUE READING

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