AFM imaging of protein movements: histone H2A-H2B release during nucleosome remodeling.

@article{Bash2006AFMIO,
  title={AFM imaging of protein movements: histone H2A-H2B release during nucleosome remodeling.},
  author={Ralph C Bash and Hong Wang and Carl Anderson and Jaya G. Yodh and Gordon L. Hager and Stuart M. Lindsay and Dennis Lohr},
  journal={FEBS letters},
  year={2006},
  volume={580 19},
  pages={4757-61}
}
Being able to follow assembly/disassembly reactions of biomolecular complexes directly at the single molecule level would be very useful. Here, we use an AFM technique that can simultaneously obtain topographic images and identify the locations of a specific type of protein within those images to monitor the histone H2A component of nucleosomes acted on by human Swi-Snf, an ATP-dependent nucleosome remodeling complex. Activation of remodeling results in significant H2A release from nucleosomes… CONTINUE READING

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