AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

@article{Deshpande2014AF10RP,
  title={AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.},
  author={A. Deshpande and Anagha Deshpande and A. Sinha and Liying M. Chen and Jenny Chang and A. Cihan and Maurizio Fazio and Chun-Wei Chen and N. Zhu and R. Koche and Liuda Dzhekieva and Gladys Ibanez and S. Dias and D. Banka and A. Krivtsov and M. Luo and R. Roeder and J. Bradner and K. Bernt and S. Armstrong},
  journal={Cancer cell},
  year={2014},
  volume={26 6},
  pages={
          896-908
        }
}
Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to monomethylation (H3K79me1) at HOX loci as hematopoietic cells mature, thus coinciding with a decrease in HOX gene expression. We show that H3K79 methyltransferase activity as well as H3K79me1-to-H3K79me2 conversion is regulated by the DOT1L cofactor AF10. AF10 inactivation reverses leukemia-associated epigenetic profiles, precludes… Expand
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