AETIOLOGY AND PATHOGENESIS OF POSTINFECTIVE TROPICAL MALABSORPTION (TROPICAL SPRUE)

@article{Cook1984AETIOLOGYAP,
  title={AETIOLOGY AND PATHOGENESIS OF POSTINFECTIVE TROPICAL MALABSORPTION (TROPICAL SPRUE)},
  author={Gordon C. Cook},
  journal={The Lancet},
  year={1984},
  volume={323},
  pages={721-723}
}
  • G. Cook
  • Published 31 March 1984
  • Medicine
  • The Lancet

Tropical sprue and subclinical enteropathy: a vision for the nineties.

There is a group of gastrointestinal disorders mainly affecting the small intestine of individuals predominantly living in and less often visiting or returning from the Third World, usually the tropics, and ranging from asymptomatic structural and/or functional abnormalities of the gastrointestinal mucosa to a fully symptomatic condition highlighted by malabsorption of nutrients.

Leadling artile-Tropical infection ofthe gastrointestinal tract and liver series Persisting diarrhoea and malabsorption

  • Medicine
This review does not deal specifically with causes of chronic diarrhoeal disease in the indigenous populations of tropical and subtropical countries; these include ileocaecal tuberculosis, Mediterranean and Burkitt's lymphomas, Kala-azar, chronic calcific pancreatitis, chronic liver disease, severe protein malnutrition, and pellagra.

Persisting diarrhoea and malabsorption.

This review does not deal specifically with causes of chronic diarrhoeal disease in the indigenous populations of tropical and subtropical countries; these include ileocaecal tuberculosis, Mediterranean and Burkitt's lymphomas, Kala-azar, chronic calcific pancreatitis, chronic liver disease, severe protein malnutrition, and pellagra.

Tropical malabsorption

The management of tropical sprue is reviewed and an algorithm for its investigation and management is presented, finding that investigations to exclude specific infective, immunological or inflammatory causes are important before considering Tropical sprue as a diagnosis.

Post-infective malabsorption in the temperate zone.

Infective gastroenteritis and its relationship to reduced gastric acidity.

  • G. Cook
  • Medicine
    Scandinavian journal of gastroenterology. Supplement
  • 1985
The best evidence for increased incidence of specific bacterial infection in the presence of achlorhydria relates to the nontyphoid salmonelloses and among parasitic infections, the most impressive evidence relates to giardiasis and strongyloidiasis.

[Tropical sprue in an expatriate].

The pathology of malabsorption: current concepts

Intestinal malabsorption results from a wide variety of causes, which can most easily be organized into three groups:munocompromised patients, mucosal and mural causes, and microbial causes.

'The tropics in our bathroom': chronic diarrhoea after return from the tropics.

The classification of chronic diarrhoea following a visit to the tropics is essentially the same as that for acute diarrhoeas, but malabsorption is an important feature of chronic diarrhea.

Sequelae of traveler's diarrhea: focus on postinfectious irritable bowel syndrome.

  • B. Connor
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
A fuller understanding of these pathophysiological mechanisms will lead to a more directed therapeutic approach and, perhaps, a reevaluation of prophylaxis for traveler's diarrhea as a means of primary prevention of PI-IBS.
...

References

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Delayed small-intestinal transit in tropical malabsorption.

  • G. Cook
  • Medicine
    British medical journal
  • 1978
The time of breath hydrogen appearance after oral lactulose was determined in 98 patients in London who had been to the tropics, indicating that their mouth-caecum transit rate was abnormally slow.

Morphologic effects of folic acid and vitamin B12 on the jejunal lesion of tropical sprue.

A group of previously untreated patients was subjected to a controlled series of observations to determine how the jejunum responds to folate-B12 therapy, finding it unlikely that the primary or sole cause of tropical sprue is folate -B12 deficiency.

Immunological changes in tropical sprue.

The results suggest that the small intestinal enterocyte abnormality in tropical sprue is not the result of a primary immunological process but that the observed alterations are a sequelae of mucosal damage and compromised integrity of the mucosal barrier.

Malabsorption in Africa.

  • G. Cook
  • Medicine
    Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 1974

The Aetiology and Mechanism of Steatorrhoea

Steatorrhoea, often associated with generalized malnutrition and avitaminosis, is observed in coeliac disease, tropical and non-tropical sprue, gastro-jejuno-colic fistula, gastrectomy, pancreatitis

Military tropical sprue from South-east Asia.

British Servicemen and their families in South-east Asia form a relatively homogeneous group in whom tropical sprue is seen with some frequency, and is unlikely to be malnourished.

TROPICAL SPRUE IN EXPATRIATES FROM THE TROPICS LIVING IN THE CONTINENTAL UNITED STATES

The results of clinical, laboratory and therapeutic observations conducted over a seven year period in 40 expatriates from the tropics who presented in New York City with overt tropical sprue have

Enterotoxigenic intestinal bacteria in tropical sprue.

Abstract Bacterial growth was seen in cultures of fasting or postprandial midjejunal aspirates from 10 of 11 patients with tropical sprue; 2 of 4 healthy North Americans; and 7 of 9 Puerto Rican co...