AEG-1/MTDH/LYRIC: clinical significance.

  title={AEG-1/MTDH/LYRIC: clinical significance.},
  author={Devanand Sarkar and Paul B Fisher},
  journal={Advances in cancer research},
"Gain-of-function" and "loss-of-function" studies in human cancer cells and analysis of a transgenic mouse model have convincingly established that AEG-1/MTDH/LYRIC performs a seminal role in regulating proliferation, invasion, angiogenesis, metastasis, and chemoresistance, the salient defining hallmarks of cancer. These observations are strongly buttressed by clinicopathologic correlations of AEG-1/MTDH/LYRIC expression in a diverse array of cancers distinguishing AEG-1/MTDH/LYRIC as an… CONTINUE READING

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