ADVAN-style analytical solutions for common pharmacokinetic models.

Abstract

INTRODUCTION The analytical solutions to compartmental pharmacokinetic models are well known, but have not been presented in a form that easily allows for complex dosing regimen and changes in covariate/parameter values that may occur at discrete times within and/or between dosing intervals. METHODS Laplace transforms were used to derive ADVAN-style… (More)
DOI: 10.1016/j.vascn.2015.03.004

Topics

  • Presentations referencing similar topics