ADR1c mutations enhance the ability of ADR1 to activate transcription by a mechanism that is independent of effects on cyclic AMP-dependent protein kinase phosphorylation of Ser-230.

@article{Denis1992ADR1cME,
  title={ADR1c mutations enhance the ability of ADR1 to activate transcription by a mechanism that is independent of effects on cyclic AMP-dependent protein kinase phosphorylation of Ser-230.},
  author={Clyde L Denis and St233phane Fontaine and Diana Chase and Bruce E. Kemp and L T Bemis},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 4},
  pages={1507-14}
}
Four ADR1c mutations that occur close to Ser-230 of the Saccharomyces cerevisiae transcriptional activator ADR1 and which greatly enhance the ability of ADR1 to activate ADH2 expression under glucose-repressed conditions have been shown to reduce or eliminate cyclic AMP-dependent protein kinase (cAPK) phosphorylation of Ser-230 in vitro. In addition, unregulated cAPK expression in vivo blocks ADH2 depression in an ADR1-dependent fashion in which ADR1c mutations display decreased sensitivity to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Glucose repres

Landano, C. L. Denis
1992

Negative regulation of transcription of the Saccharomyces cerevisiae catalase T ( CflF 1 ) gene by cAMP is mediated by a positive control element

L. T. Bemis
EMBO J • 1991

Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine

D. R. Knighton, J. Zheng, +3 authors J. M. Sowadski
1991

Similar Papers

Loading similar papers…