ADR1 activation domains contact the histone acetyltransferase GCN5 and the core transcriptional factor TFIIB.

@article{Chiang1996ADR1AD,
  title={ADR1 activation domains contact the histone acetyltransferase GCN5 and the core transcriptional factor TFIIB.},
  author={Y. C. Chiang and Philip B. Komarnitsky and Dale Chase and Clyde L Denis},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 50},
  pages={32359-65}
}
The yeast transcriptional activator ADR1, which is required for ADH2 and peroxisomal gene expression, contains four separable and partially redundant activation domains (TADs). Mutations in ADA2 or GCN5, encoding components of the ADA coactivator complex involved in histone acetylation, severely reduced LexA-ADR1-TAD activation of a LexA-lacZ reporter gene. Similarly, the ability of the wild-type ADR1 gene to activate an ADH2-driven promoter was compromised in strains deleted for ADA2 or GCN5… CONTINUE READING

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