ADP-ribosylation factor is functionally and physically associated with the Golgi complex.

@article{Stearns1990ADPribosylationFI,
  title={ADP-ribosylation factor is functionally and physically associated with the Golgi complex.},
  author={Tim Stearns and Mark C. Willingham and David Botstein and Richard A. Kahn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 3},
  pages={
          1238-42
        }
}
ADP-ribosylation factor (ARF) is a ubiquitous, highly conserved 21-kDa GTP-binding protein, first identified in animal cells as the cofactor required for the in vitro ADP-ribosylation of the stimulatory regulatory subunit of adenylate cyclase, Gs, by cholera toxin. As the relevance of this activity to in vivo function is unknown, we have taken advantage of the conserved nature of ARF to study its function in Saccharomyces cerevisiae. Yeast cells bearing an arf1 null mutation display a number of… CONTINUE READING
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