ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis.

@article{Koch2003ADPribosylationFP,
  title={ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis.},
  author={Thomas Koch and Lars-Ove Brandenburg and Stefan Schulz and Yingjian Liang and Jochen Klein and Volker Hollt},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 11},
  pages={9979-85}
}
Agonist exposure of many G protein-coupled receptors induces a rapid receptor phosphorylation and uncoupling from G proteins. Resensitization of these desensitized receptors requires endocytosis and subsequent dephosphorylation. Using a yeast two-hybrid screen, the rat mu-opioid receptor (MOR1, also termed MOP) was found to be associated with phospholipase D2 (PLD2), a phospholipid-specific phosphodiesterase located in the plasma membrane, which has been implicated in the formation of… CONTINUE READING

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