ADP-ribosylating bacterial enzymes for the targeted control of mucosal tolerance and immunity.

  • Nils Y Lycke
  • Published 2004 in Annals of the New York Academy of Sciences
The questions of whether mucosal tolerance and IgA immunity are mutually exclusive or can coexist and whether they represent priming of the local immune system through the same or different activation pathways are addressed. Two strategies were attempted: the first using cholera toxin (CT) or the enzymatically inactive receptor-binding B subunit of CT (CTB… CONTINUE READING