ADP-ribosylated proteins as old and new drug targets for anticancer therapy: the example of ARF6.

@article{Dani2012ADPribosylatedPA,
  title={ADP-ribosylated proteins as old and new drug targets for anticancer therapy: the example of ARF6.},
  author={Nadia Dani and Arm{\'e}nio Jorge Moura Barbosa and Alberto Del Rio and Maria Grazia di Girolamo},
  journal={Current pharmaceutical design},
  year={2012},
  volume={19 4},
  pages={
          624-33
        }
}
Post-translational modifications of cellular proteins by mono- or poly-ADP-ribosylation are associated with numerous cellular processes. ADP-ribosylation reactions are important in the nucleus, and in mitochondrial activity, stress response signaling, intracellular trafficking, and cell senescence and apoptosis decisions. These reversible reactions add ADP-ribose to target proteins via specific enzymes to form the ADP-ribosylated protein; the cleaveage of this covalent bond is performed via… CONTINUE READING
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