ADP receptors--targets for developing antithrombotic agents.

@article{Kunapuli2003ADPRF,
  title={ADP receptors--targets for developing antithrombotic agents.},
  author={Satya P Kunapuli and Zhongren Ding and Robert T. Dorsam and Soochong Kim and Swaminathan Murugappan and Todd M. Quinton},
  journal={Current pharmaceutical design},
  year={2003},
  volume={9 28},
  pages={
          2303-16
        }
}
Platelet P2 receptors--P2Y1, P2Y12, and P2X1--constitute the means by which adenine nucleotides can activate platelets. Coactivation of the Galphaq-coupled P2Y1 and Galphai2-coupled P2Y12 receptors is necessary for ADP-mediated platelet activation, which forms the basis of using P2 antagonists as antithrombotic drugs. P2Y1 receptor antagonists inhibit… CONTINUE READING