ADP is not Involved in Thrombin-induced Aggregation of Thrombocytes of a Non-mammalian Vertebrate

@article{Belamarich1968ADPIN,
  title={ADP is not Involved in Thrombin-induced Aggregation of Thrombocytes of a Non-mammalian Vertebrate},
  author={F. A. Belamarich and D. Shepro and M. Kien},
  journal={Nature},
  year={1968},
  volume={220},
  pages={509-510}
}
PLATELETS are aggregated in vivo and in vitro by ADP1,2. Several agents such as thrombin, collagen and certain fatty acids cause aggregation by releasing ADP3. We reported that ADP, 5-hydroxytryptamine and adrenaline do not bring about aggregation of nucleated thrombocytes of chicken (Gallus domesticus), turtle (Pseudemys scripta elegans), alligator (Alligator mississippensis) and smooth dogfish (Mustelus canis), whereas thrombin does4,5. Thrombin seems to aggregate platelets by releasing ADP… Expand
Thrombocyte aggregation in rainbow trout
Abstract 1. 1. Thrombocytes from mature rainbow trout ( Sahmo gairdneri ) aggregated in vitro after addition of ADP, ATP, collagen, epinephrine, 5-hydroxytryptamine or thrombin to thrombocyte-richExpand
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It is suggested that acetylation of thrombin (or prothrombin) by aspirin may account for the action of this compound on platelets and it is possible that its role may be to facilitate aggregation through an effect on platelet surface charge. Expand
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Comparison of hemostasis in sea turtles to other vertebrates could provide a framework for understanding the structure/function and evolution of these pathways and their individual components. Expand
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  • Biology, Medicine
  • Comparative biochemistry and physiology. A, Comparative physiology
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Chicken thrombocyte activation by PAF required Ca2+ and appeared to be mediated through a specific receptor for PAF, and secreted [3H]serotonin when stimulated in vitro with platelet-activating factor, collagen and calcium ionophore A23187. Expand
Avian thrombocyte aggregation and shape change in vitro.
TLDR
Avian thrombocytes resemble mammalian platelets in their ability to undergo shape change with ADP but differ in that they do not aggregate withADP. Expand
THE CONTROL OF PLATELET RESPONSIVENESS BY AGENTS THAT INFLUENCE CYCLIC AMP METABOLISM
  • D. Mills, J. Smith
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1972
TLDR
The actions of some inhibitors of aggregation are studied by measuring the accumulation of radioactive cyclic AMP in platelets previously labeled by incubation with I4C-adenine, which is rapidly incorporated into the cytoplasmic adenine nucleotide pool. Expand
Adenine nucleotides in thrombocytes of birds
  • B. Wachowicz
  • Biology, Medicine
  • Cell biochemistry and function
  • 1984
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Analysis of free nucleotide composition of both avian thrombocytes and pig platelets showed quantitative differences in the level of adenine nucleotides, andMalonyldialdehyhyde (MDA) production due to thrombin was observed in both platelets and throm bocytes. Expand
Great Britain CHANGES IN THROMBOCYTE ULTRASTRUCTURE DURING CLOT RETRACTION *
The contraction of the entire thrombocyte appears to be a primary factor in the retracting mechanism of dogfish (Musteltis canis) in vitro blood clots. Microtubules probably account for theExpand
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The ultrastructure of the resting thrombocytes of the snake Waglerophis merremii and the process of ADP aggregation are studied to suggest a process of evolutional specialization since thromBocytes in the majority of non-mammal vertebrates are not aggregated by ADP. Expand
Aggregation of duck thrombocytes by 5-hydroxytryptamine.
Abstract The nucleated thrombocytes of Aylesbury ducks are aggregated by relatively low concentrations of 5-hydroxytryptamine (5-HT, serotonin) and by a saline suspension of duck tendons. AggregationExpand
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References

SHOWING 1-7 OF 7 REFERENCES
In vitro Studies of Aggregation of Non-mammalian Thrombocytes
TLDR
Although the term thrombocyte is frequently used as a synonym for the mammalian platelet, in this paper it is used solely to describe the non-mammalian haemostatic cell. Expand
Microdetermination of adenosine diphosphate and adenosine triphosphate in plasma with firefly luciferase system.
TLDR
A simple device for “dark” injection of firefly lantern extract into solutions is described, and the intensity of the initial light flash of the luciferin-luciferase reaction was found to be proportional to the concentration of ATP and of ADP, after conversion to ATP with the pyruvate-kinase system. Expand
Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets
TLDR
Adenosine Diphosphate in Red Cells as a Factor in the Adhesiveness of Human Blood Platelets and the Adhesion of Human blood Platelets is studied. Expand