ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq.

@article{Ohlmann2000ADPIP,
  title={ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq.},
  author={Philippe Ohlmann and Anita Eckly and Monique Freund and J. P. Cazenave and Stefan Offermanns and Christian Gachet},
  journal={Blood},
  year={2000},
  volume={96 6},
  pages={2134-9}
}
Platelets from Galphaq knockout mice are unable to aggregate in response to physiological agonists like adenosine 5'-diphosphate (ADP), thromboxane A(2), thrombin, or collagen, although shape change still occurs in response to all of these agonists except ADP. ADP-induced platelet aggregation results from simultaneous activation of the purinergic P2Y(1) receptor coupled to calcium mobilization and shape change and of a distinct P2 receptor, P2cyc, coupled through Gi to adenylyl cyclase… CONTINUE READING