ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase

@inproceedings{Mayer2011ADPRS,
  title={ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase},
  author={Faith V. Mayer and Richard B. Heath and Elizabeth Underwood and Matthew J. Sanders and David Carmena and Rhonda R. McCartney and Fiona C. Leiper and Bing Xiao and Chun Jing and Philip A. Walker and Lesley F. Haire and Roksana W Ogrodowicz and Stephen R. Martin and Martin Schmidt and Steven J. Gamblin and David Carling},
  booktitle={Cell metabolism},
  year={2011}
}
The SNF1 protein kinase complex plays an essential role in regulating gene expression in response to the level of extracellular glucose in budding yeast. SNF1 shares structural and functional similarities with mammalian AMP-activated protein kinase. Both kinases are activated by phosphorylation on a threonine residue within the activation loop segment of the catalytic subunit. Here we show that ADP is the long-sought metabolite that activates SNF1 in response to glucose limitation by protecting… CONTINUE READING
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