ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety

@article{Partyka2016ADN1184AM,
  title={ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety},
  author={A. Partyka and A. Wąsik and M. Jastrzębska-Więsek and P. Mierzejewski and P. Bienkowski and M. Kołaczkowski and A. Wesołowska},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2016},
  volume={389},
  pages={593 - 602}
}
Behavioral and psychological symptoms of dementia (BPSD) include apathy, sleep problems, irritability, wandering, elation, agitation/aggression, and mood disorders such as depression and/or anxiety. Elderly patients are usually treated with second-generation antipsychotics; however, they present not enough efficacy against all symptoms observed. Hence, there still is an unmet need for novel pharmacotherapeutic agents targeted BPSD. A novel arylsulfonamide derivative ADN-1184 has been developed… Expand
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NDT_A_309818 2105..2127
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