ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety

  title={ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety},
  author={A. Partyka and A. Wąsik and M. Jastrzębska-Więsek and P. Mierzejewski and P. Bienkowski and M. Kołaczkowski and A. Wesołowska},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  pages={593 - 602}
Behavioral and psychological symptoms of dementia (BPSD) include apathy, sleep problems, irritability, wandering, elation, agitation/aggression, and mood disorders such as depression and/or anxiety. Elderly patients are usually treated with second-generation antipsychotics; however, they present not enough efficacy against all symptoms observed. Hence, there still is an unmet need for novel pharmacotherapeutic agents targeted BPSD. A novel arylsulfonamide derivative ADN-1184 has been developed… Expand
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NDT_A_309818 2105..2127
1Department of Clinical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland; 2Department of Radioligands, Faculty of Pharmacy, Jagiellonian University MedicalExpand
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Searching for new anxiolytic agents among derivatives of 11-dialkylaminoethyl-2,3,4,5-tetrahydrodiazepino[1,2-a]benzimidazole.
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  • 2021
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ADN‐1184 a monoaminergic ligand with 5‐HT6/7 receptor antagonist activity: pharmacological profile and potential therapeutic utility
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Antipsychotics for the Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD)
These drugs have been used for many decades, but in the last years new compounds have been marketed with the promise of comparable efficacy but less frequent adverse effects (especially extra-pyramidal side effects) challenged by data showing a potential increase in adverse cerebrovascular side effects and mortality. Expand
Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression
Data indicate that the selective 5-HT(6) receptor antagonist SB-399885had specific effects, indicative of this compound's anxiolytic and antidepressant potential. Expand
Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics
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Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression.
  • L. Wang, J. Shofer, +5 authors E. Peskind
  • Psychology, Medicine
  • The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2009
Prazosin was well tolerated and improved behavioral symptoms in patients with agitation/aggression in AD, and increased up to 6 mg/day using a flexible dosing algorithm. Expand
Role of 5-HT in stress, anxiety, and depression
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Enhancement of antipsychotic-like effects by combined treatment with the α1-adrenoceptor antagonist prazosin and the dopamine D2 receptor antagonist raclopride in rats
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