ADMET in silico modelling: towards prediction paradise?

@article{Waterbeemd2003ADMETIS,
  title={ADMET in silico modelling: towards prediction paradise?},
  author={Han van de Waterbeemd and Eric A. Gifford},
  journal={Nature reviews. Drug discovery},
  year={2003},
  volume={2 3},
  pages={192-204}
}
Following studies in the late 1990s that indicated that poor pharmacokinetics and toxicity were important causes of costly late-stage failures in drug development, it has become widely appreciated that these areas should be considered as early as possible in the drug discovery process. However, in recent years, combinatorial chemistry and high-throughput screening have significantly increased the number of compounds for which early data on absorption, distribution, metabolism, excretion (ADME… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 122 references

The Practice of Medicinal Chemistry 2nd (ed Wermuth, L

H. Van de Waterbeemd, S. Rose
2003

20 / 20 Vision : A brave new world of drug development

R. J. Anderson
Curr . Drug Disc . • 2002

A brave new world of drug development

Anderson, R. J. 2020 Vision
Curr. Drug Disc. 25–29 • 2002

A fast virtual screening filter for cytochrome P450 3A4 inhibition liability of compound libraries

J. Zuegge, U. Fechner, +3 authors G. Schneider
Quant. Struct. Act. Relat • 2002

A new approach

N. A. Kratochwil, W. Huber, +3 authors P. Predicting plasmas protein binding of drugs
Biochem. Pharmacol. 64, 1355–1374 • 2002

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