ADMET considerations for restless leg syndrome drug treatments.

  title={ADMET considerations for restless leg syndrome drug treatments.},
  author={Stefano de Biase and Giovanni Merlino and Simone Lorenzut and Mariarosaria Valente and Gian Luigi Gigli},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={8 10},
INTRODUCTION Restless legs syndrome (RLS) is a common neurological disorder that might impair nocturnal rest causing decreased alertness, depressed mood, reduced job performance, and poor quality of life. In patients affected by severe RLS, a pharmacological treatment is mandatory. AREAS COVERED The present review is based on a search using PubMed from 1994 to 2012. It is focused on the Absorption, Distribution, Metabolism, Elimination and Toxicology (ADMET) characteristics of the most used… CONTINUE READING