ADME of Antibody–Maytansinoid Conjugates

  title={ADME of Antibody–Maytansinoid Conjugates},
  author={Hans K. Erickson and J. G. Lambert},
  journal={The AAPS Journal},
The concept of treating cancer with antibody-drug conjugates (ADCs) has gained momentum with the favorable activity and safety of trastuzumab emtansine (T-DM1), SAR3419, and lorvotuzumab mertansine (IMGN901). All three ADCs utilize maytansinoid cell-killing agents which target tubulin and suppress microtubule dynamics. Each ADC utilizes a different optimized chemical linker to attach the maytansinoid to the antibody. Characterizing the absorption, distribution, metabolism, and excretion (ADME… CONTINUE READING


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