ADME/PK as part of a rational approach to drug discovery.

  title={ADME/PK as part of a rational approach to drug discovery.},
  author={Eddershaw and Beresford and Bayliss},
  journal={Drug discovery today},
  volume={5 9},
Rational drug discovery requires an early appraisal of all factors impacting on the likely success of a drug candidate in the subsequent preclinical, clinical and commercial phases of drug development. The study of absorption, distribution, metabolism, excretion and pharmacokinetics (ADME/PK) has developed into a relatively mature discipline in drug discovery through the application of well-established in vitro and in vivo methodologies. The availability of improved analytical and automation… CONTINUE READING

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