ADHD symptoms in neurometabolic diseases: Underlying mechanisms and clinical implications

  title={ADHD symptoms in neurometabolic diseases: Underlying mechanisms and clinical implications},
  author={Selina Cannon Homaei and Helene Barone and Rune Kleppe and Nibal Betari and Andreas Reif and Jan Haavik},
  journal={Neuroscience and biobehavioral reviews},
Neurometabolic diseases (NMDs) are typically caused by genetic abnormalities affecting enzyme functions, which in turn interfere with normal development and activity of the nervous system. Although the individual disorders are rare, NMDs are collectively relatively common and often lead to lifelong difficulties and high societal costs. Neuropsychiatric manifestations, including ADHD symptoms, are prominent in many NMDs, also when the primary biochemical defect originates in cells and tissues… 

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