ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry

@inproceedings{Bierut2012ADH1BIA,
  title={ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry},
  author={Laura J. Bierut and Alison M. Goate and Naomi Breslau and Eric Otto Johnson and Sarah E Bertelsen and Louis Fox and Arpana Agrawal and Kathleen K Bucholz and Richard A Grucza and Victor M. Hesselbrock and John R. Kramer and Samuel Kuperman and John J I Nurnberger and Bernice Porjesz and Nancy L. Saccone and Marc A Schuckit and Jay A. Tischfield and Jen Chyong Wang and Tatiana Foroud and John P. Rice and Howard J. Edenberg},
  booktitle={Molecular Psychiatry},
  year={2012}
}
A coding variant in alcohol dehydrogenase 1B (ADH1B) (rs1229984) that leads to the replacement of Arg48 with His48 is common in Asian populations and reduces their risk for alcoholism, but because of very low allele frequencies the effects in European or African populations have been difficult to detect. We genotyped and analyzed this variant in three large European and African-American case–control studies in which alcohol dependence was defined by the Diagnostic and Statistical Manual of… CONTINUE READING
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