ADF/cofilin use an intrinsic mode of F-actin instability to disrupt actin filaments

@article{Galkin2003ADFcofilinUA,
  title={ADF/cofilin use an intrinsic mode of F-actin instability to disrupt actin filaments},
  author={Vitold E Galkin and Albina Orlova and M S Vanloock and Alexander Shvetsov and Emil Reisler and Edward H. Egelman},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={163},
  pages={1057 - 1066}
}
Proteins in the ADF/cofilin (AC) family are essential for rapid rearrangements of cellular actin structures. They have been shown to be active in both the severing and depolymerization of actin filaments in vitro, but the detailed mechanism of action is not known. Under in vitro conditions, subunits in the actin filament can treadmill; with the hydrolysis of ATP driving the addition of subunits at one end of the filament and loss of subunits from the opposite end. We have used electron… CONTINUE READING

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