ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signaling

@article{Rehklau2012ADFcofilinPT,
  title={ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signaling},
  author={Katharina Rehklau and Christine B. Gurniak and Marcus Conrad and Eckhard Friauf and Michael C Ott and Marco B. Rust},
  journal={Cell Death and Differentiation},
  year={2012},
  volume={19},
  pages={958-967}
}
Non-muscle cofilin (n-cofilin) is a member of the ADF/cofilin family of actin depolymerizing proteins. Recent studies reported a mitochondrial translocation of n-cofilin during apoptosis. As these studies also revealed impaired cytochrome c release and a block in apoptosis upon small interfering RNA-mediated n-cofilin knockdown, n-cofilin was postulated to be essential for apoptosis induction. To elucidate the general importance of ADF/cofilin activity for apoptosis, we exposed mouse embryonic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

The actin cytoskeleton and cell survival

  • JM Field
  • Recent Advances in Clinical Medicine
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…