ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose.

@article{Foretz1999ADD1SREBP1cIR,
  title={ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose.},
  author={Marc Foretz and Corinne Pacot and Isabelle Dugail and Patricia Lemarchand and C{\'e}cile Guichard and Xavier Le Li{\`e}pvre and C Berthelier-Lubrano and Bruce M. Spiegelman and Jae Bum Kim and Pascal Ferr{\'e} and Fabienne Foufelle},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 5},
  pages={
          3760-8
        }
}
The transcription of genes encoding proteins involved in the hepatic synthesis of lipids from glucose is strongly stimulated by carbohydrate feeding. It is now well established that in the liver, glucose is the main activator of the expression of this group of genes, with insulin having only a permissive role. While ADD1/SREBP-1 has been implicated in lipogenic gene expression through temporal association with food intake and ectopic gain-of-function experiments, no genetic evidence for a… CONTINUE READING
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