ADCY5 Couples Glucose to Insulin Secretion in Human Islets

  title={ADCY5 Couples Glucose to Insulin Secretion in Human Islets},
  author={David J Hodson and Ryan K. Mitchell and Lorella Marselli and Timothy J. Pullen and Silvia Gimeno Brias and Francesca Semplici and Katy L. Everett and Dermot M. F. Cooper and Marco Bugliani and Piero Marchetti and Vanessa Lavallard and Domenico Bosco and Lorenzo Piemonti and Paul R. V. Johnson and Stephen S J Hughes and Daliang Li and Wen-hong Li and A M James Shapiro and Guy A Rutter},
Single nucleotide polymorphisms (SNPs) within the ADCY5 gene, encoding adenylate cyclase 5, are associated with elevated fasting glucose and increased type 2 diabetes (T2D) risk. Despite this, the mechanisms underlying the effects of these polymorphic variants at the level of pancreatic β-cells remain unclear. Here, we show firstly that ADCY5 mRNA expression in islets is lowered by the possession of risk alleles at rs11708067. Next, we demonstrate that ADCY5 is indispensable for coupling… CONTINUE READING
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