ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity

@inproceedings{Cachat2014ADAR1EH,
  title={ADAR1 enhances HTLV-1 and HTLV-2
replication through inhibition of PKR activity},
  author={Anne Cachat and Sandrine Alais and S{\'e}bastien Alain Chevalier and Chlo{\'e} Journo and Floriane Fusil and H{\'e}l{\`e}ne Dutartre and Adrien Boniface and Nga Ling Ko and Antoine Gessain and François-Lo{\"i}c Cosset and Rodolphe Susp{\`e}ne and J P Vartanian and Renaud Mahieux},
  booktitle={Retrovirology},
  year={2014}
}
The role of innate immunity in general and of type I interferon (IFN-I) in particular in HTLV-1 pathogenesis is still a matter of debate. ADAR1-p150 is an Interferon Stimulated Gene (ISG) induced by IFN-I that can edit viral RNAs. We therefore investigated whether it could play the role of an anti-HTLV factor. We demonstrate here that ADAR1 is also expressed in the absence of IFN stimulation in activated primary T-lymphocytes that are the natural target of this virus and in HTLV-1 or HTLV-2… CONTINUE READING
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