ADAR proteins: double-stranded RNA and Z-DNA binding domains.

  title={ADAR proteins: double-stranded RNA and Z-DNA binding domains.},
  author={Pierre Barraud and Fr{\'e}d{\'e}ric Hai-Trieu Allain},
  journal={Current topics in microbiology and immunology},
Adenosine deaminases acting on RNA (ADAR) catalyze adenosine to inosine editing within double-stranded RNA (dsRNA) substrates. Inosine is read as a guanine by most cellular processes and therefore these changes create codons for a different amino acid, stop codons or even a new splice-site allowing protein diversity generated from a single gene. We review here the current structural and molecular knowledge on RNA editing by the ADAR family of protein. We focus especially on two types of nucleic… CONTINUE READING