ADAMs, cell migration and cancer

  title={ADAMs, cell migration and cancer},
  author={Joaqu{\'i}n Arribas and Joan Josep Bech-Serra and Bel{\'e}n Santiago-Josefat},
  journal={Cancer and Metastasis Reviews},
The ADAMs are modular type I transmembrane proteins that contain a metalloprotease and a disintegrin-like domain. In fact, ADAM stands for “A Disintegrin And Metalloprotease” and has become the most widespread name to designate this group of proteins. Alternative terms such as metalloprotease disintegrins or MDC (metalloprotease/disintegrin/cysteinerich) are currently less used. Although ADAMs are frequently referred to as a family, they constitute a subfamily of the M10 family that, in turn… CONTINUE READING