ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer

@article{Du2013ADAMTS9IA,
  title={ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer},
  author={Wan Du and Shiyan Wang and Q. Zhou and X-d Li and Jun Chu and Zhijie Chang and Qian Tao and E K W Ng and J Fang and Joseph J Y Sung and J. Yu},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={3319-3328}
}
Using genome-wide promoter methylation analysis, we identified a disintegrin-like and metalloprotease with thrombospondin type 1 motif 9 (ADAMTS9) is methylated in cancer. We aim to clarify its epigenetic inactivation, biological function and clinical implication in gastric cancer. ADAMTS9 was silenced in 6 out of 8 gastric cancer cell lines. The loss of ADAMTS9 expression was regulated by promoter hypermethylation and could be restored by demethylation agent. Ectopic expression of ADAMTS9 in… Expand
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  • Weilin Sun, G. Ma, +9 authors J. Deng
  • Medicine
  • Cell death & disease
  • 2021
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