ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure -A Possible Novel Therapeutic Target.

@article{Omura2019ADAMTS8PT,
  title={ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure -A Possible Novel Therapeutic Target.},
  author={J. Omura and K. Satoh and Nobuhiro Kikuchi and T. Satoh and R. Kurosawa and M. Nogi and Tomohiro Ohtsuki and Md. Elias Al-Mamun and M. A. Siddique and N. Yaoita and S. Sunamura and S. Miyata and Y. Hoshikawa and Y. Okada and H. Shimokawa},
  journal={Circulation research},
  year={2019}
}
Rationale: Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling with aberrant pulmonary artery smooth muscle cells (PASMCs) proliferation, endothelial dysfunction, and extracellular matrix remodeling. Objective: Right ventricular (RV) failure is an important prognostic factor in PAH. Thus, we need to elucidate a novel therapeutic target in both PAH and RV failure. Methods and Results: We performed microarray analysis in PASMCs from patients with PAH (PAH… Expand
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