ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro.

@article{Ostertag2016ADAMTS13AC,
  title={ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro.},
  author={Eric M. Ostertag and Stephen Kacir and Michelle M. Thiboutot and Gayathri Gulendran and X Long Zheng and Douglas B Cines and Donald L Siegel},
  journal={Transfusion},
  year={2016},
  volume={56 7},
  pages={1763-74}
}
BACKGROUND Acquired thrombotic thrombocytopenia purpura (TTP) is a life-threatening illness caused by autoantibodies that decrease the activity of ADAMTS13, the von Willebrand factor-cleaving protease. Despite efficacy of plasma exchange, mortality remains high and relapse is common. Improved therapies may come from understanding the diversity of pathogenic autoantibodies on a molecular or genetic level. Cloning comprehensive repertoires of patient autoantibodies can provide the necessary tools… CONTINUE READING