ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro.

@article{Ostertag2016ADAMTS13AC,
  title={ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro.},
  author={E. Ostertag and Stephen Kacir and Michelle Thiboutot and Gayathri Gulendran and X. Zheng and D. Cines and D. Siegel},
  journal={Transfusion},
  year={2016},
  volume={56 7},
  pages={
          1763-74
        }
}
  • E. Ostertag, Stephen Kacir, +4 authors D. Siegel
  • Published 2016
  • Biology, Medicine
  • Transfusion
  • BACKGROUND Acquired thrombotic thrombocytopenia purpura (TTP) is a life-threatening illness caused by autoantibodies that decrease the activity of ADAMTS13, the von Willebrand factor-cleaving protease. Despite efficacy of plasma exchange, mortality remains high and relapse is common. Improved therapies may come from understanding the diversity of pathogenic autoantibodies on a molecular or genetic level. Cloning comprehensive repertoires of patient autoantibodies can provide the necessary tools… CONTINUE READING
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