ADAMTS13 Gene Mutations in Children with Hemolytic Uremic Syndrome


We investigated ADAMTS13 activity as well as the ADAMTS13 gene mutation in children with hemolytic uremic syndrome (HUS). Eighteen patients, including 6 diarrhea- negative (D-HUS) and 12 diarrhea-associated HUS (D+HUS) patients, were evaluated. The extent of von Willebrand factor (VWF) degradation was assayed by multimer analysis, and all exons of the… (More)
DOI: 10.3349/ymj.2011.52.3.530

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