ADAMTS1: a matrix metalloprotease with angioinhibitory properties.

  title={ADAMTS1: a matrix metalloprotease with angioinhibitory properties.},
  author={M Luisa Iruela-Arispe and Darren R. Carpizo and Alfonso Luque},
  journal={Annals of the New York Academy of Sciences},
Neovascularization is a hallmark of cancer progression. Suppression of the angiogenic response in tumors has been associated with inhibition and even regression of total tumor mass. Therefore, the derivation of synthetic or natural products that could interfere with proangiogenic signaling pathways can greatly impact cancer therapy. Using the antiangiogenic motifs in thrombospondin-1, we have recently cloned METH1/ADAMTS1, a secreted metalloproteinase with three thrombospondin-1, and shown that… CONTINUE READING