ADAMTS-4 and biglycan are expressed at high levels and co-localize to podosomes during endothelial cell tubulogenesis in vitro.

Abstract

Proteolysis of the extracellular matrix influences vascular growth. We examined the expression of ADAMTS-1, -4, and -5 metalloproteinases and their proteoglycan substrates versican, decorin, and biglycan as human umbilical vein endothelial cells (HUVECs) formed tubes within type I collagen gels in vitro. Tubulogenic and control HUVEC cultures expressed low… (More)
DOI: 10.1369/0022155413507727

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@article{Obika2014ADAMTS4AB, title={ADAMTS-4 and biglycan are expressed at high levels and co-localize to podosomes during endothelial cell tubulogenesis in vitro.}, author={Masanari Obika and Robert B. Vernon and Michel D. Gooden and Kathleen R. Braun and Christina K. Chan and Thomas N Wight}, journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society}, year={2014}, volume={62 1}, pages={34-49} }