ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo.

@article{Rocks2008ADAMTS1MP,
  title={ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo.},
  author={Natacha Rocks and Genevi{\`e}ve Paulissen and Florence Quesada-Calvo and Carine Munaut and M L Alvarez Gonzalez and Maud M. Gu{\'e}ders and Jonathan Hacha and Christine Gilles and J. -M. Foidart and Agn{\`e}s Noel and Didier Cataldo},
  journal={Cancer research},
  year={2008},
  volume={68 22},
  pages={9541-50}
}
ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motifs), the first described member of the ADAMTS family, is differentially expressed in various tumors. However, its exact role in tumor development and progression is still unclear. The aim of this study was to investigate the effects of ADAMTS-1 transfection in a bronchial epithelial tumor cell line (BZR) and its potential to modulate tumor development. ADAMTS-1 overexpression did not affect in vitro cell properties such as (a… CONTINUE READING
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Emerging roles of ADAM and ADAMTS metalloproteinases in cancer

  • N Rocks, G Paulissen, M El Hour
  • Biochimie
  • 2008
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