• DOI:10.1677/JME.1.01735
Corpus ID: 31242070

ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary.

@article{Shozu2005ADAMTS1II,
  title={ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary.},
  author={M. Shozu and N. Minami and H. Yokoyama and M. Inoue and H. Kurihara and K. Matsushima and K. Kuno},
  journal={Journal of molecular endocrinology},
  year={2005},
  volume={35 2},
  pages={
          343-55
        }
}

• M. Shozu, N. Minami, +4 authors K. Kuno
• Published 2005
• Biology, Medicine
• Journal of molecular endocrinology

To clarify the role of disintegrin-like and metalloproteinase with thrombospondin type I motifs-1 (ADAMTS-1) in ovarian function, we examined abnormalities in ovulatory processes, folliculogenesis and the vascular system of ADAMTS-1 null ovaries. First, when immature female mice were treated with pregnant mare serum gonadotropin (PMSG)/human chorionic gonadotropin (hCG), the number of ovulated oocytes was markedly decreased in ADAMTS-1 null mice in comparison to ADAMTS-1 (+/-) controls. The… Expand

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