ADAM9 is involved in pathological retinal neovascularization.

  title={ADAM9 is involved in pathological retinal neovascularization.},
  author={Victor H Guaiquil and Steven L Swendeman and Tsunehiko Yoshida and Sai H. Chavala and Peter Anthony Campochiaro and Carl P Blobel},
  journal={Molecular and cellular biology},
  volume={29 10},
Pathological ocular neovascularization, caused by diabetic retinopathy, age-related macular degeneration, or retinopathy of prematurity, is a leading cause of blindness, yet much remains to be learned about its underlying causes. Here we used oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) to assess the contribution of the metalloprotease-disintegrin ADAM9 to ocular neovascularization in mice. Pathological neovascularization in both the OIR and CNV models… CONTINUE READING


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