ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population

@article{Sakagami2006ADAM33PA,
  title={ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population},
  author={T. Sakagami and N. Jinnai and T. Nakajima and T. Sekigawa and T. Hasegawa and E. Suzuki and I. Inoue and F. Gejyo},
  journal={Journal of Human Genetics},
  year={2006},
  volume={52},
  pages={66-72}
}
AbstractMultiple single nucleotide polymorphisms (SNPs) within ADAM33 have been reported to be associated with asthma and bronchial hyper-responsiveness in Caucasian populations. We examined whether these SNPs contribute to a predisposition to asthma, especially aspirin-intolerant asthma (AIA), in the Japanese population. Ten polymorphic sites (ST+4, ST+7, T1, T2, T+1, V-3, V-2, V-1, V4, V5) were genotyped in 102 AIA patients, 282 aspirin-tolerant asthma (ATA) patients and 120 control (CTR… Expand
Association of ADAM33 polymorphisms with childhood asthma in a northern Chinese population.
TLDR
The ADAM33 gene plays an important role in facilitating susceptibility to childhood asthma in this Han Chinese population and three SNPs were strongly associated with Childhood asthma in children of northern China compared to healthy controls. Expand
Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population
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Polymorphisms of the ADAM33 gene may modify individual susceptibility to AR and AS in a Chinese Han population, and may participate in the susceptibility of AS. Expand
ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population.
TLDR
It is confirmed that ADAM33 polymorphisms are associated with asthma susceptibility in the Li population and confirm the uniqueness of the Li minority population within China. Expand
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TLDR
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Association of IL-4 and ADAM33 Gene Polymorphisms with Asthma in an Indian Population
TLDR
Analysis of single nucleotide polymorphisms of IL-4 and ADAM33 revealed that there is no association of these SNPs with asthma indicating that other SNPs of these genes or other genes might be involved in the manifestation of asthma. Expand
A possible association of EMID2 polymorphisms with aspirin hypersensitivity in asthma
TLDR
Evidence is provided that EMID2 may be a susceptible genetic factor for aspirin hypersensitivity among asthmatics in Korean population and could cause meaningful deficits in the upper and lower airways among AIA patients. Expand
Association of ADAM33 gene polymorphisms with asthma in Indian children
TLDR
Results suggest that ADAM33 gene polymorphisms may modify individual susceptibility to develop childhood asthma in the Indian population. Expand
Association of ADAM33 gene polymorphisms with adult concomitant allergic rhinitis and asthma in Chinese Han population
TLDR
The SNPs (V4 G/C, T2 A/G, T1 G/A, and Q − 1A/G) of the ADAM33 gene may be the causal variants in ARA disease. Expand
Haplotypic association of ADAM33 (T+1, S+1 and V − 3) gene variants in genetic susceptibility to asthma in Indian population
TLDR
SNPs, T+1, S+1 and V − 3 do not individually confer any significant risk of asthma or its severity, but haplotype analysis suggests all three polymorphisms together play an important role in the disease of asthma. Expand
Association of a disintegrin and metalloprotease 33 gene polymorphisms with asthma.
TLDR
It is suggested that the T2 and ST+5 ADAM33 gene polymorphisms do not confer a significant risk of asthma or affect its severity in the population investigated. Expand
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