ADAM19/adamalysin 19 structure, function, and role as a putative target in tumors and inflammatory diseases.

@article{Qi2009ADAM19adamalysin1S,
  title={ADAM19/adamalysin 19 structure, function, and role as a putative target in tumors and inflammatory diseases.},
  author={Bin Qi and Robert G. Newcomer and Qing-Xiang Amy Sang},
  journal={Current pharmaceutical design},
  year={2009},
  volume={15 20},
  pages={
          2336-48
        }
}
A disintegrin and metalloproteinase 19 (ADAM19, or adamalysin 19) is a cell surface glycoprotein with a signal sequence, a prodomain, a metalloproteinase domain, a disintegrin domain, a cysteine-rich domain, a epidermal growth factor-like domain, a transmembrane domain, and a cytoplasmic domain. It is an endopeptidase that cleaves extracellular matrix proteins and sheds growth factors and cytokines such as neuregulins, heparin-binding epidermal growth factor, tumor necrosis factor (TNF)-alpha… CONTINUE READING
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