ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis.

@article{Mulder2012ADAM17UI,
  title={ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis.},
  author={Gemma M. Mulder and Wynand B. W. H. Melenhorst and Johanna W. A. M. Celie and Niels J. Kloosterhuis and J. L. Hillebrands and Rutger J Ploeg and Marc A. J. Seelen and Lydia Visser and Marcory R. C. F. van Dijk and Harry van Goor},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2012},
  volume={27 5},
  pages={2114-22}
}
BACKGROUND Interstitial fibrosis and tubular atrophy (IF/TA) is an important cause of renal function loss and ischaemia-reperfusion (I/R) injury is considered to play an important role in its pathophysiology. The aim of the present study was to investigate the role of a disintegrin and metalloproteinase 17 (ADAM17) in human renal allograft disease and in experimental I/R injury of the kidney. METHODS We studied the expression of ADAM17 messenger RNA (mRNA) in IF/TA and control kidneys by… CONTINUE READING
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