ADAM17-mediated shedding of FcγRIIIA on human NK cells: identification of the cleavage site and relationship with activation.

@article{Lajoie2014ADAM17mediatedSO,
  title={ADAM17-mediated shedding of FcγRIIIA on human NK cells: identification of the cleavage site and relationship with activation.},
  author={Laurie Lajoie and Nicolas Congy-Jolivet and Armelle Bolzec and Val{\'e}rie Gouilleux-Gruart and Elodie Sicard and Hsueh Cheng Sung and Frank Peiretti and Thierry Moreau and Henri Vi{\'e} and B{\'e}atrice Cl{\'e}menceau and Gilles Thibault},
  journal={Journal of immunology},
  year={2014},
  volume={192 2},
  pages={741-51}
}
FcγRIIIA/CD16A, the low-affinity receptor for the IgG Fc portion expressed on human CD56(dim) NK cells and involved in Ab-dependent cell cytotoxicity, is shed upon NK cell activation. We found that recombinant a disintegrin and metalloprotease (ADAM) 17 cleaved the ectodomain of FcγRIIIA/CD16A and a peptide for which the sequence encompasses aa 191-201 of… CONTINUE READING

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