ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site.


Protein ectodomain shedding is crucial for cell-cell interactions because it controls the bioavailability of soluble tumor necrosis factor-α (TNFα) and ligands of the epidermal growth factor (EGF) receptor, and the release of many other membrane proteins. Various stimuli can rapidly trigger ectodomain shedding, yet much remains to be learned about the… (More)
DOI: 10.1242/jcs.069997


5 Figures and Tables